Core histone

Trichostatin A ( TSA ), one of the inhibitors of HDACs , was used to determine the effects of core histone hyperacetylation on development ability and expression level of relational gene mRNA in different developmental embryos .

本实验通过一种组蛋白去乙酰化酶抑制剂TSA来诱导不同时期胚胎核心组蛋白高乙酰化，观察其对早期胚胎发育能力及相关基因mRNA表达水平变化的影响。

The level of histone acetylation is regulated by the histone acetyltransferase ( HATS ) with the acetylation modification of core histone . This further control gene transcription and gene expression regulation which resulted in gene activation or silence .

组蛋白乙酰转移酶（HATs）通过对核心组蛋白进行乙酰化修饰来调节组蛋白的乙酰化水平，从而调控基因的转录，参与基因的表达，并由此介导基因的激活或沉默。

Core histone around which DNA is wound plays a key role as a terminal protein of inflammatory signal transduction on gene transcription .

染色体核心组蛋白分子作为各种炎症因子和炎症信号转导的关键性终端蛋白质分子，具有基因转录开关分子的功能，其活性受组蛋白转乙酰酶/脱乙酰酶（HAT/HDAC）的调节。

Acetylation of lysine residues of core histone N terminal domains has been found correlatively associated with transcriptional activation in eukaryotes .

真核细胞组蛋白N端赖氨酸残基的乙酰化与基因的转录激活有关。

Formation of nucleosomes requires extensive histone-histone and histone-DNA interactions occurred mainly within the central histone-fold domain of each core histone .

核小体的形成还需要组蛋白－组蛋白之间，组蛋白－DNA之间的结合反应，这些反应主要发生于核心组蛋白中心结构域，即：组蛋白折叠区域。

Modulation of core histone acetylation by histone deacetylase ( HDAC ) and histone acetyl - transferase ( HAT ) alters chromatin structure and dynamically affects transcriptional regulation .

组蛋白去乙酰酶（HistoneDeacetylase，HDAC）抑制剂可促进组蛋白乙酰化，调节染色质结构和基因转录。

H4 is the most conservative core histone in eucaryotic cells , ranging from fungi to man , and its acetylation is restricted only to the four lysines ( residues 5,8,12 , and 16 ) .

H4是真核细胞中最保守的一种核心组蛋白，从真菌到人类的组蛋白H4，其乙酰化只限制在四个赖氨酸上（残基5、8、12和16）。

Nucleosome dynamics , one of the core areas of histone protein research projects , is largely concerned with the interaction between DNA and histone octamer and properties of the formation of nucleosome complex .

核小体动力学主要研究DNA与组蛋白的相互作用下核小体受力、结构形成过程，是蛋白质组研究计划的核心研究内容之一。